Publication: Multiplexed protein maps link subcellular organization to cellular state
Multiplexed protein maps link subcellular organization to cellular state
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Gut, G., Herrmann, M. D., & Pelkmans, L. (2018). Multiplexed protein maps link subcellular organization to cellular state. Science, 361, eaar7042. https://doi.org/10.1126/science.aar7042
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Being able to visualize protein localizations within cells and tissues by means of immuno-fluorescence microscopy has been key to developments in cell biology and beyond. Gut et al. present a high-throughput method that achieves the detection of more than 40 different proteins in biological samples across multiple spatial scales. This allows the simultaneous quantification of their expression levels in thousands of single cells; captures their detailed subcellular distribution to various compartments, organelles, and cellular structur
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- Gut, Gabriele
- Herrmann, Markus D
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Gut, G., Herrmann, M. D., & Pelkmans, L. (2018). Multiplexed protein maps link subcellular organization to cellular state. Science, 361, eaar7042. https://doi.org/10.1126/science.aar7042