Publication: Targeting glia with N-Acetylcysteine modulates brain glutamate and behaviors relevant to neurodevelopmental disorders in C57BL/6J mice
Targeting glia with N-Acetylcysteine modulates brain glutamate and behaviors relevant to neurodevelopmental disorders in C57BL/6J mice
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Durieux, A. M. S., Fernandes, C., Murphy, D., Labouesse, M. A., Giovanoli, S., Meyer, U., Li, Q., So, P.-W., & McAlonan, G. (2015). Targeting glia with N-Acetylcysteine modulates brain glutamate and behaviors relevant to neurodevelopmental disorders in C57BL/6J mice. Frontiers in Behavioral Neuroscience, 9:343. https://doi.org/10.3389/fnbeh.2015.00343
Abstract
Abstract
Abstract
An imbalance between excitatory (E) glutamate and inhibitory (I) GABA transmission may underlie neurodevelopmental conditions such as autism spectrum disorder (ASD) and schizophrenia. This may be direct, through alterations in synaptic genes, but there is increasing evidence for the importance of indirect modulation of E/I balance through glial mechanisms. Here, we used C57BL/6J mice to test the hypothesis that striatal glutamate levels can be shifted by N-acetylcysteine (NAC), which acts at the cystine-glutamate antiporter of glial c
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Creators (Authors)
- Durieux, Alice M S
- Fernandes, Cathy
- Murphy, Declan
- Labouesse, Marie Anais
- Giovanoli, Sandra
- Meyer, Urs
- Li, Qi
- So, Po-Wah
- McAlonan, Grainne
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Citations
Durieux, A. M. S., Fernandes, C., Murphy, D., Labouesse, M. A., Giovanoli, S., Meyer, U., Li, Q., So, P.-W., & McAlonan, G. (2015). Targeting glia with N-Acetylcysteine modulates brain glutamate and behaviors relevant to neurodevelopmental disorders in C57BL/6J mice. Frontiers in Behavioral Neuroscience, 9:343. https://doi.org/10.3389/fnbeh.2015.00343
