Publication: The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection
The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection
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Bieri, M., Hendrickx, R., Bauer, M., Yu, B., Jetzer, T., Dreier, B., Mittl, P. R. E., Sobek, J., Plückthun, A., Greber, U. F., & Hemmi, S. (2021). The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection. PLoS Pathogens, 17(12), e1010083. https://doi.org/10.1371/journal.ppat.1010083
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Mammalian adenoviruses (AdVs) comprise more than ~350 types including over 100 human (HAdVs) and just three mouse AdVs (MAdVs). While most HAdVs initiate infection by high affinity/avidity binding of their fiber knob (FK) protein to either coxsackievirus AdV receptor (CAR), CD46 or desmoglein (DSG)-2, MAdV-1 (M1) infection requires arginine-glycine-aspartate (RGD) binding integrins. To identify the receptors mediating MAdV infection we generated five novel reporter viruses for MAdV-1/-2/-3 (M1, M2, M3) transducing permissive murine (m
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Bieri, M., Hendrickx, R., Bauer, M., Yu, B., Jetzer, T., Dreier, B., Mittl, P. R. E., Sobek, J., Plückthun, A., Greber, U. F., & Hemmi, S. (2021). The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infection. PLoS Pathogens, 17(12), e1010083. https://doi.org/10.1371/journal.ppat.1010083
