Publication: Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
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Steullet, P., Cabungcal, J. H., Coyle, J., Didriksen, M., Gill, K., Grace, A. A., Hensch, T. K., LaMantia, A. S., Lindemann, L., Maynard, T. M., Meyer, U., Morishita, H., O’Donnell, P., Puhl, M., Cuenod, M., & Do, K. Q. (2017). Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia. Molecular Psychiatry, 22, 936–943. https://doi.org/10.1038/mp.2017.47
Abstract
Abstract
Abstract
Parvalbumin inhibitory interneurons (PVIs) are crucial for maintaining proper excitatory/inhibitory balance and high-frequency neuronal synchronization. Their activity supports critical developmental trajectories, sensory and cognitive processing, and social behavior. Despite heterogeneity in the etiology across schizophrenia and autism spectrum disorder, PVI circuits are altered in these psychiatric disorders. Identifying mechanism(s) underlying PVI deficits is essential to establish treatments targeting in particular cognition. On t
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Creators (Authors)
- Steullet, P
- Cabungcal, J H
- Coyle, J
- Didriksen, M
- Gill, K
- Grace, A A
- Hensch, T K
- LaMantia, A S
- Lindemann, L
- Maynard, T M
- Meyer, Urs
- Morishita, H
- O'Donnell, P
- Puhl, M
- Cuenod, M
- Do, K Q
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Citations
Steullet, P., Cabungcal, J. H., Coyle, J., Didriksen, M., Gill, K., Grace, A. A., Hensch, T. K., LaMantia, A. S., Lindemann, L., Maynard, T. M., Meyer, U., Morishita, H., O’Donnell, P., Puhl, M., Cuenod, M., & Do, K. Q. (2017). Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia. Molecular Psychiatry, 22, 936–943. https://doi.org/10.1038/mp.2017.47
