Aqua-complexes of pyrimidine-4,6-dicarboxylic acid and its monoester with organometallic fac-[M(CO)3]+ (M = Re and 99mTc) core as radiopharmaceutical probes: Synthesis and characterization

Mukiza, Janvier; Habarurema, Gratien; Sezirahiga, Jurdas; Mukabagorora, Theonille; Nkuranga, Jean Bosco; Uwambajineza, Tite; Muyizere, Theoneste; Blacque, Olivier; Baziga, Gervais

doi:10.1016/j.jorganchem.2024.123348

Citations

Citation copied

Mukiza, J., Habarurema, G., Sezirahiga, J., Mukabagorora, T., Nkuranga, J. B., Uwambajineza, T., Muyizere, T., Blacque, O., & Baziga, G. (2024). Aqua-complexes of pyrimidine-4,6-dicarboxylic acid and its monoester with organometallic fac-[M(CO)3]+ (M = Re and 99mTc) core as radiopharmaceutical probes: Synthesis and characterization. Journal of Organometallic Chemistry, 1021, 123348. https://doi.org/10.1016/j.jorganchem.2024.123348

Abstract

The current study highlights on the synthesis and characterization of aqua-complexes of the fac-M(CO)(3) (M = Re and Tc-99m) core with pyrimidine-4,6-dicarboxylic acid (H(2)pmdc) and its monoester 6-(ethoxycarbonyl)pyrimidine-4-carboxylic acid (Hetpmdc), which are the model for future design of imaging and therapeutic radiopharmaceuticals. Complexes [M(CO)(3)(OH2)(Hpmdc)] (M = Re (1) and Tc-99m (2)) were formed from the reaction of H2pmdc with [Re(CO)(5)Br] in water and aqueous solution of Tc-99m(CO)(3)(OH2)(3) respectively.