Publication: Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor
Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor
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Stichling, N., Suomalainen, M., Flatt, J. W., Schmid, M., Pacesa, M., Hemmi, S., Jungraithmayr, W., Maler, M. D., Freudenberg, M. A., Plückthun, A., May, T., Köster, M., Fejer, G., & Greber, U. F. (2018). Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor. PLoS Pathogens, 14(3), e1006914. https://doi.org/10.1371/journal.ppat.1006914
Abstract
Abstract
Abstract
Macrophages are a diverse group of phagocytic cells acting in host protection against stress, injury, and pathogens. Here, we show that the scavenger receptor SR-A6 is an entry receptor for human adenoviruses in murine alveolar macrophage-like MPI cells, and important for production of type I interferon. Scavenger receptors contribute to the clearance of endogenous proteins, lipoproteins and pathogens. Knockout of SR-A6 in MPI cells, anti-SR-A6 antibody or the soluble extracellular SR-A6 domain reduced adenovirus type-C5 (HAdV-C5) bin
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- Stichling, Nicole
- Suomalainen, Maarit
- Flatt, Justin W
- Schmid, Markus
- Pacesa, Martin
- Hemmi, Silvio
- Jungraithmayr, Wolfgang
- Maler, Mareike D
- Freudenberg, Marina A
- May, Tobias
- Köster, Mario
- Fejer, György
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Stichling, N., Suomalainen, M., Flatt, J. W., Schmid, M., Pacesa, M., Hemmi, S., Jungraithmayr, W., Maler, M. D., Freudenberg, M. A., Plückthun, A., May, T., Köster, M., Fejer, G., & Greber, U. F. (2018). Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor. PLoS Pathogens, 14(3), e1006914. https://doi.org/10.1371/journal.ppat.1006914
