Publication: Attenuating human fear memory retention with minocycline: a randomized placebo-controlled trial
Attenuating human fear memory retention with minocycline: a randomized placebo-controlled trial
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Xia, Y., Wehrli, J., Abivardi, A., Hostiuc, M., Kleim, B., & Bach, D. R. (2024). Attenuating human fear memory retention with minocycline: a randomized placebo-controlled trial. Translational Psychiatry, 14(1), 28. https://doi.org/10.1038/s41398-024-02732-2
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Abstract
Pavlovian fear conditioning is widely used as a pre-clinical model to investigate methods for prevention and treatment of anxiety and stress-related disorders. In this model, fear memory consolidation is thought to require synaptic remodeling, which is induced by signaling cascades involving matrix metalloproteinase 9 (MMP-9). Here we investigated the effect of the tetracycline antibiotic minocycline, an inhibitor of MMP-9, on fear memory retention. We conducted a pre-registered, randomized, double-blind, placebo-controlled trial in N
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- Xia, Yanfang
- Wehrli, Jelena
- Abivardi, Aslan
- Hostiuc, Madalina
- Kleim, Birgit
- Bach, Dominik R
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Xia, Y., Wehrli, J., Abivardi, A., Hostiuc, M., Kleim, B., & Bach, D. R. (2024). Attenuating human fear memory retention with minocycline: a randomized placebo-controlled trial. Translational Psychiatry, 14(1), 28. https://doi.org/10.1038/s41398-024-02732-2
