Publication: A novel murine model for sporadic, malignant peripheral nerve sheath tumors, driven by BrafV600E and Pten loss
A novel murine model for sporadic, malignant peripheral nerve sheath tumors, driven by BrafV600E and Pten loss
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Debbache, J., Gwerder, M., Rushing, E., & Sommer, L. (2025). A novel murine model for sporadic, malignant peripheral nerve sheath tumors, driven by BrafV600E and Pten loss. Disease Models & Mechanisms, 18(11), online. https://doi.org/10.1242/dmm.052471
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Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited therapeutic options. Here, we present a novel sporadic murine model of Nf1 wild-type MPNST, driven by conditional expression of oncogenic BrafV600E and Pten loss in the glial lineage using the Plp1::CreERT2 driver. This model allows for highly penetrant and rapid tumor induction through spontaneous formation, localized initiation, or cell transplantation. Comparative analysis with Tyr::CreERT2-driven melanoma revealed striking phenotypic divergence d
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Debbache, J., Gwerder, M., Rushing, E., & Sommer, L. (2025). A novel murine model for sporadic, malignant peripheral nerve sheath tumors, driven by BrafV600E and Pten loss. Disease Models & Mechanisms, 18(11), online. https://doi.org/10.1242/dmm.052471
