Publication: Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells
Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells
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He, J., Nascakova, Z., Leary, P., Papa, G., Valenta, T., Basler, K., & Müller, A. (2023). Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells. Science Advances, 9(46), eadh0322. https://doi.org/10.1126/sciadv.adh0322
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Helicobacter pylori infection is a major risk factor for the development of gastric cancer. The bacteria reside in close proximity to gastric surface mucous as well as stem and progenitor cells. Here, we take advantage of wild-type and genetically engineered murine gastric organoids and organoid-derived monolayers to study the cellular targets of H. pylori-induced DNA damage and replication stress and to explore possible interactions with preexisting gastric cancer driver mutations. We find using alkaline comet assay, single-molecule
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- He, Jiazhuo
- Nascakova, Zuzana
- Leary, Peter
- Papa, Giovanni
- Valenta, Tomas
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He, J., Nascakova, Z., Leary, P., Papa, G., Valenta, T., Basler, K., & Müller, A. (2023). Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells. Science Advances, 9(46), eadh0322. https://doi.org/10.1126/sciadv.adh0322
