Publication: DNA methylation epigenetically regulates gene expression in Burkholderia cenocepacia and controls biofilm formation, cell aggregation, and motility
DNA methylation epigenetically regulates gene expression in Burkholderia cenocepacia and controls biofilm formation, cell aggregation, and motility
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Vandenbussche, I., Sass, A., Pinto-Carbó, M., Mannweiler, O., Eberl, L., & Coenye, T. (2020). DNA methylation epigenetically regulates gene expression in Burkholderia cenocepacia and controls biofilm formation, cell aggregation, and motility. MSphere, 5(4), 00455–20. https://doi.org/10.1128/msphere.00455-20
Abstract
Abstract
Abstract
Respiratory tract infections by the opportunistic pathogen Burkholderia cenocepacia often lead to severe lung damage in cystic fibrosis (CF) patients. New insights in how to tackle these infections might emerge from the field of epigenetics, as DNA methylation is an important regulator of gene expression. The present study focused on two DNA methyltransferases (MTases) in B. cenocepacia strains J2315 and K56-2 and their role in regulating gene expression. In silico predicted DNA MTase genes BCAL3494 and BCAM0992 were deleted in both s
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Creators (Authors)
- Vandenbussche, Ian
- Sass, Andrea
- Pinto-Carbó, Marta
- Mannweiler, Olga
- Coenye, Tom
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Citations
Vandenbussche, I., Sass, A., Pinto-Carbó, M., Mannweiler, O., Eberl, L., & Coenye, T. (2020). DNA methylation epigenetically regulates gene expression in Burkholderia cenocepacia and controls biofilm formation, cell aggregation, and motility. MSphere, 5(4), 00455–20. https://doi.org/10.1128/msphere.00455-20
