Publication: The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6
The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6
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Küffer, A., Lakkaraju, A. K. K., Mogha, A., Petersen, S. C., Airich, K., Doucerain, C., Marpakwar, R., Bakirci, P., Senatore, A., Monnard, A., Schiavi, C., Nuvolone, M., Grosshans, B., Hornemann, S., Bassilana, F., Monk, K. R., & Aguzzi, A. (2016). The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature, 536(7617), 464–468. https://doi.org/10.1038/nature19312
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Ablation of the cellular prion protein PrPC leads to a chronic demyelinating polyneuropathy affecting Schwann cells. Neuron-restricted expression of PrPC prevents the disease1, suggesting that PrPC acts in trans through an unidentified Schwann cell receptor. Here we show that the cAMP concentration in sciatic nerves from PrPC-deficient mice is reduced, suggesting that PrPC acts via a G protein-coupled receptor (GPCR). The amino-terminal flexible tail (residues 23–120) of PrPC triggered a concentration-dependent increase in cAMP in pri
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- Küffer, Alexander
- Mogha, Amit
- Petersen, Sarah C
- Airich, Kristina
- Doucerain, Cédric
- Marpakwar, Rajlakshmi
- Bakirci, Pamela
- Senatore, Assunta
- Monnard, Arnaud
- Schiavi, Carmen
- Nuvolone, Mario
- Grosshans, Bianka
- Hornemann, Simone
- Bassilana, Frederic
- Monk, Kelly R
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Küffer, A., Lakkaraju, A. K. K., Mogha, A., Petersen, S. C., Airich, K., Doucerain, C., Marpakwar, R., Bakirci, P., Senatore, A., Monnard, A., Schiavi, C., Nuvolone, M., Grosshans, B., Hornemann, S., Bassilana, F., Monk, K. R., & Aguzzi, A. (2016). The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature, 536(7617), 464–468. https://doi.org/10.1038/nature19312
