Publication: Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation
Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation
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Mueller, F. S., Richetto, J., Hayes, L. N., Zambon, A., Pollak, D. D., Sawa, A., Meyer, U., & Weber-Stadlbauer, U. (2019). Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation. Brain, Behavior, and Immunity, 80, 406–418. https://doi.org/10.1016/j.bbi.2019.04.019
Abstract
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Maternal immune activation (MIA) models that are based on administration of the viral mimetic, poly(I:C), are widely used as experimental tools to study neuronal and behavioral dysfunctions in relation to immune-mediated neurodevelopmental disorders and mental illnesses. Evidence from investigations in non-pregnant rodents suggests that different poly(I:C) products can vary in terms of their immunogenicity, even if they are obtained from the same vendor. The present study aimed at extending these findings to pregnant mice, while also
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- Mueller, Flavia S
- Richetto, Juliet
- Hayes, Lindsay N
- Zambon, Alice
- Pollak, Daniela D
- Sawa, Akira
- Meyer, Urs
- Weber-Stadlbauer, Ulrike
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Mueller, F. S., Richetto, J., Hayes, L. N., Zambon, A., Pollak, D. D., Sawa, A., Meyer, U., & Weber-Stadlbauer, U. (2019). Influence of poly(I:C) variability on thermoregulation, immune responses and pregnancy outcomes in mouse models of maternal immune activation. Brain, Behavior, and Immunity, 80, 406–418. https://doi.org/10.1016/j.bbi.2019.04.019
