Publication: Nocturnal gamma-hydroxybutyrate reduces cortisol awakening response and morning kyrunenine pathway metabolites in healthy volunteers
Nocturnal gamma-hydroxybutyrate reduces cortisol awakening response and morning kyrunenine pathway metabolites in healthy volunteers
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Dornbierer, D. A., Boxler, M., Voegel, C. D., Stucky, B., Steuer, A. E., Binz, T. M., Baumgartner, M. R., Baur, D. M., Quednow, B. B., Kraemer, T., Seifritz, E., Landolt, H.-P., & Bosch, O. G. (2019). Nocturnal gamma-hydroxybutyrate reduces cortisol awakening response and morning kyrunenine pathway metabolites in healthy volunteers. International Journal of Neuropsychopharmacology, 22(10), 631–639. https://doi.org/10.1093/ijnp/pyz047
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Background Gamma-hydroxybutyrate (GHB; or sodium oxybate) is an endogenous GHB-/GABAB receptor agonist. It is approved for the application in narcolepsy and has been proposed for potential treatment of Alzheimer’s and Parkinson’s disease, fibromyalgia, and depression, all of which involve neuro-immunological processes. Tryptophan catabolites (TRYCATs), the cortisol awakening response (CAR), and brain derived neurotrophic factor (BDNF) have been suggested as peripheral biomarkers of neuropsychiatric disorders. GHB has been shown to in
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- Dornbierer, Dario A
- Boxler, M
- Stucky, Benjamin
- Steuer, A E
- Baur, Diego M
- Kraemer, T
- Seifritz, E
- Landolt, Hans-Peter
- Bosch, O G
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Dornbierer, D. A., Boxler, M., Voegel, C. D., Stucky, B., Steuer, A. E., Binz, T. M., Baumgartner, M. R., Baur, D. M., Quednow, B. B., Kraemer, T., Seifritz, E., Landolt, H.-P., & Bosch, O. G. (2019). Nocturnal gamma-hydroxybutyrate reduces cortisol awakening response and morning kyrunenine pathway metabolites in healthy volunteers. International Journal of Neuropsychopharmacology, 22(10), 631–639. https://doi.org/10.1093/ijnp/pyz047
