Publication: Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling
Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling
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Rubbiani, R., Wu, W., Naik, A., Larocca, M., Schneider, L., Padrutt, R., Babu, V., König, C., Hinger, D., Maake, C., Ferrari, S., Gasser, G., & Spingler, B. (2020). Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling. Chemical Communications, 56, 14373–14376. https://doi.org/10.1039/d0cc05196a
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Abstract
Novel tetraplatinated metalloporphyrin-based photosensitizers (PSs) are reported, which show excellent phototoxic indexes (PIs) up to 5800 against HeLa cells, which is, to the best of our knowledge, the highest value reported for any porphyrin so far. Furthermore, 67Zn isotope labelling allowed the determination of the ratio of zinc to platinum inside the cells using ICP-MS.
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- Rubbiani, Riccardo
- Wu, Wenyu
- Naik, Anu
- Larocca, Michele
- Schneider, Lukas
- Padrutt, Roxane
- Babu, Vipin
- König, Christiane
- Hinger, Doris
- Maake, Caroline
- Gasser, Gilles
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Rubbiani, R., Wu, W., Naik, A., Larocca, M., Schneider, L., Padrutt, R., Babu, V., König, C., Hinger, D., Maake, C., Ferrari, S., Gasser, G., & Spingler, B. (2020). Studying the cellular distribution of highly phototoxic platinated metalloporphyrins using isotope labelling. Chemical Communications, 56, 14373–14376. https://doi.org/10.1039/d0cc05196a
