Publication: Highly Phototoxic Transplatin‐Modified Distyryl‐BODIPY Photosensitizers for Photodynamic Therapy
Highly Phototoxic Transplatin‐Modified Distyryl‐BODIPY Photosensitizers for Photodynamic Therapy
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Padrutt, R., Babu, V., Klingler, S., Kalt, M., Schumer, F., Anania, M. I., Schneider, L., & Spingler, B. (2021). Highly Phototoxic Transplatin‐Modified Distyryl‐BODIPY Photosensitizers for Photodynamic Therapy. ChemMedChem, 16(4), 694–701. https://doi.org/10.1002/cmdc.202000702
Abstract
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We report the synthesis of the first transplatin‐BODIPY conjugates for application in photodynamic therapy (PDT). The distyryl BODIPYs containing two iodine atoms were designed to absorb in the red region, easily undergo intersystem crossing for efficient singlet oxygen generation, and additionally offer the possibility for coordination with mono‐activated transplatin. We were able to demonstrate that coordination of the BODIPYs with a mono‐activated transplatin increases the phototoxic index of the photosensitizers significantly, giv
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Creators (Authors)
- Padrutt, Roxane
- Babu, Vipin
- Klingler, Simon
- Kalt, Martina
- Schumer, Frank
- Anania, Maria I
- Schneider, Lukas
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Padrutt, R., Babu, V., Klingler, S., Kalt, M., Schumer, F., Anania, M. I., Schneider, L., & Spingler, B. (2021). Highly Phototoxic Transplatin‐Modified Distyryl‐BODIPY Photosensitizers for Photodynamic Therapy. ChemMedChem, 16(4), 694–701. https://doi.org/10.1002/cmdc.202000702
