Publication: Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork
Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork
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Kanagaraj, R., Saydam, N., Garcia, P. L., Zheng, L., & Janscak, P. (2006). Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Research, 34, 5217–5231. https://doi.org/10.1093/nar/gkl677
Abstract
Abstract
Abstract
The role of the human RECQ5beta helicase in the maintenance of genomic stability remains elusive. Here we show that RECQ5beta promotes strand exchange between arms of synthetic forked DNA structures resembling a stalled replication fork in a reaction dependent on ATP hydrolysis. BLM and WRN can also promote strand exchange on these structures. However, in the presence of human replication protein A (hRPA), the action of these RecQ-type helicases is strongly biased towards unwinding of the parental duplex, an effect not seen with RECQ5
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- Kanagaraj, R
- Saydam, N
- Garcia, P L
- Zheng, L
- Janscak, Pavel
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Citations
Kanagaraj, R., Saydam, N., Garcia, P. L., Zheng, L., & Janscak, P. (2006). Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork. Nucleic Acids Research, 34, 5217–5231. https://doi.org/10.1093/nar/gkl677
