Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

Georgiadis, Foivos; Larivière, Sara; Glahn, David; Hong, L Elliot; Kochunov, Peter; Mowry, Bryan; Loughland, Carmel; Pantelis, Christos; Henskens, Frans A; Green, Melissa J; Cairns, Murray J; Michie, Patricia T; Rasser, Paul E; Catts, Stanley; Tooney, Paul; Scott, Rodney J; Schall, Ulrich; Carr, Vaughan; Quidé, Yann; Krug, Axel

doi:10.1038/s41380-024-02442-7

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Georgiadis, F., Larivière, S., Glahn, D., Hong, L. E., Kochunov, P., Mowry, B., Loughland, C., Pantelis, C., Henskens, F. A., Green, M. J., Cairns, M. J., Michie, P. T., Rasser, P. E., Catts, S., Tooney, P., Scott, R. J., Schall, U., Carr, V., Quidé, Y., … et al. (2024). Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study. Molecular Psychiatry, 29(6), 1869–1881. https://doi.org/10.1038/s41380-024-02442-7

Abstract

Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale structural alterations in schizophrenia relate to normative structural and functional connectome architecture, and systematically evaluated robustness and generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2439 adults with schizophrenia and 2867 healthy controls f