Publication: Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells
Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells
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Popovic, D., Koch, B., Kueblbeck, M., Ellenberg, J., & Pelkmans, L. (2018). Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells. Cell Systems, 7, 398–411. https://doi.org/10.1016/j.cels.2018.09.001
Abstract
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Abstract
A long-standing question in quantitative biology is the relationship between mRNA and protein levels of the same gene. Here, we measured mRNA and protein abundance, the phenotypic state, and the population context in thousands of single human cells for 23 genes by combining a unique collection of cell lines with fluorescently tagged endogenous genomic loci and quantitative immunofluorescence with branched DNA single-molecule fluorescence in situ hybridization and computer vision. mRNA and protein abundance displayed a mean single-cell
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- Popovic, Doris
- Koch, Birgit
- Kueblbeck, Moritz
- Ellenberg, Jan
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Popovic, D., Koch, B., Kueblbeck, M., Ellenberg, J., & Pelkmans, L. (2018). Multivariate Control of Transcript to Protein Variability in Single Mammalian Cells. Cell Systems, 7, 398–411. https://doi.org/10.1016/j.cels.2018.09.001
