Publication: Synthesis, Characterization, and Biological Evaluation of Iron(III)-N-Heterocyclic Carbene Complexes as Photosensitizers for Photodynamic Therapy and Chemotherapeutics against Cancer
Synthesis, Characterization, and Biological Evaluation of Iron(III)-N-Heterocyclic Carbene Complexes as Photosensitizers for Photodynamic Therapy and Chemotherapeutics against Cancer
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Zhou, L., Salluce, G., Mesdom, P., Redrado, M., Gourdon-Grünewaldt, L., Hidalgo, S., Cariou, K., Gasser, G., & Blacque, O. (2025). Synthesis, Characterization, and Biological Evaluation of Iron(III)-N-Heterocyclic Carbene Complexes as Photosensitizers for Photodynamic Therapy and Chemotherapeutics against Cancer. Inorganic Chemistry, 64(33), 17058–17065. https://doi.org/10.1021/acs.inorgchem.5c03185
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Photodynamic therapy (PDT) is a promising strategy for cancer treatment, yet the reliance on rare, expensive, and potentially toxic heavy metals limits the practical application of many current photosensitizers. In this study, we synthesized and evaluated a series of iron(III)--heterocyclic carbene (Fe(III)-NHC) complexes (-) bearing diverse substituents to explore their potential as cost-effective alternatives for cancer therapy. While none of the complexes exhibited significant singlet oxygen generation under light excitation, sever
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Zhou, L., Salluce, G., Mesdom, P., Redrado, M., Gourdon-Grünewaldt, L., Hidalgo, S., Cariou, K., Gasser, G., & Blacque, O. (2025). Synthesis, Characterization, and Biological Evaluation of Iron(III)-N-Heterocyclic Carbene Complexes as Photosensitizers for Photodynamic Therapy and Chemotherapeutics against Cancer. Inorganic Chemistry, 64(33), 17058–17065. https://doi.org/10.1021/acs.inorgchem.5c03185