Publication: Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid
Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid
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Grammatico, P., Scarpa, S., Picardo, M., Steindl, K., Nazzaro-Porro, M., & Del Porto, G. (1993). Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. Mutation Research, 300(2), 119–123. https://doi.org/10.1016/0165-1218(93)90129-2
Abstract
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Azelaic acid (AzAc) is a C9 dicarboxylic acid which has recently been shown to have some therapeutic applications in skin diseases of different aetiologies. In order to study the in vitro activity of AzAc five human malignant melanoma primary cell cultures were treated for up to 60 days with 10 mM C9 2Na; the growth characteristics were defined by growth curve and the cytogenetics by Giemsa standard technique and GTG banding technique. Our data demonstrated an inhibition in replication of all five melanomas and the disappearance of th
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Creators (Authors)
- Grammatico, P
- Scarpa, S
- Picardo, M
- Nazzaro-Porro, M
- Del Porto, G
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Grammatico, P., Scarpa, S., Picardo, M., Steindl, K., Nazzaro-Porro, M., & Del Porto, G. (1993). Karyotype modifications in human malignant melanoma cell cultures after treatment with azelaic acid. Mutation Research, 300(2), 119–123. https://doi.org/10.1016/0165-1218(93)90129-2
