Improving the turnaround time of molecular profiling for advanced non-small cell lung cancer: Outcome of a new algorithm integrating multiple approaches

Treichler, G; Hoeller, S; Rueschoff, J H; Rechsteiner, M; Britschgi, C; Arnold, F; Zoche, M; Hiltbrunner, S; Moch, H; Akhoundova, D; Opitz, I; Curioni-Fontecedro, A

doi:10.5167/uzh-235072

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Treichler, G., Hoeller, S., Rueschoff, J. H., Rechsteiner, M., Britschgi, C., Arnold, F., Zoche, M., Hiltbrunner, S., Moch, H., Akhoundova, D., Opitz, I., & Curioni-Fontecedro, A. (2023). Improving the turnaround time of molecular profiling for advanced non-small cell lung cancer: Outcome of a new algorithm integrating multiple approaches. Pathology, Research and Practice, 248, 154660. https://doi.org/10.1016/j.prp.2023.154660

Abstract

BACKGROUND

Molecular tumor profiling to identify oncogenic drivers and actionable mutations has a profound impact on how lung cancer is treated. Especially in the subgroup of non-small cell lung cancer (NSCLC), molecular testing for certain mutations is crucial in daily clinical practice and is recommended by international guidelines. To date, a standardized approach to identify druggable genetic alterations are lacking. We have developed and implemented a new diagnostic algorithm to harmonize the molecular testing of NSCLC.

PATIENT