Publication: Enhanced cellular death in liver and breast cancer cells by dual BET/BRPF1 inhibitors
Date
Date
Date
2024
Journal Article
Published version
Abstract
Abstract
Abstract
The acetylpyrrole scaffold is an acetylated lysine mimic that has been previously explored to develop bromodomain inhibitors. When tested on the hepatoma cell line Huh7 and the breast cancer cell line MDA-MB-231, a few compounds in our acetylpyrrole-thiazole library induced peculiar morphological changes, progressively causing cell death at increasing concentrations. Their evaluation on a panel of human bromodomains revealed concurrent inhibition of BRPF1 and BET bromodomains. To dissect the observed cellular effects, the acetylpyrrol
Metrics
Downloads
10 since deposited on 2024-12-06
Acq. date: 2025-11-14
Views
3 since deposited on 2024-12-06
Acq. date: 2025-11-14
Additional indexing
Creators (Authors)
- Cazzanelli, Giulia
- Dalle Vedove, Andrea
- Sbardellati, Nicolo
- Valer, Luca
- Caflisch, Amedeo
- Lolli, Graziano
Volume
Volume
Volume
33
Number
Number
Number
11
Page range/Item number
Page range/Item number
Page range/Item number
e5191
Item Type
Item Type
Item Type
Journal Article
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2024-11
Date available
Date available
Date available
2024-12-06
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
0961-8368
OA Status
OA Status
OA Status
Hybrid
Free Access at
Free Access at
Free Access at
DOI
Publisher DOI
Metrics
Downloads
10 since deposited on 2024-12-06
Acq. date: 2025-11-14
Views
3 since deposited on 2024-12-06
Acq. date: 2025-11-14
Hybrid Open Access
Loading...
