Publication: Defining Molecular Mechanisms Regulating FAN1 Protein Stability
Defining Molecular Mechanisms Regulating FAN1 Protein Stability
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Collotta, G. (2025). Defining Molecular Mechanisms Regulating FAN1 Protein Stability. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-270791
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Human FAN1 (FANCD2/FANCI-associated nuclease 1) is a structure-specific DNA repair nuclease involved in DNA interstrand-crosslink (ICL) processing, and multiple genome stability maintenance pathways. In recent years, FAN1 has gained particular attention due to genome-wide association studies linking it to Huntington’s disease (HD), an incurable neurodegenerative disorder caused by somatic expansion of CAG repeats in mutant huntingtin (mHTT). Typical for DNA repair nucleases, FAN1 activity must be tightly controlled by protein-protein
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Collotta, G. (2025). Defining Molecular Mechanisms Regulating FAN1 Protein Stability. (Dissertation, University of Zurich) https://doi.org/10.5167/uzh-270791
