Publication: Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier
Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier
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Keller, A., Nuvolone, M., Abakumova, I., Chincisan, A., Reimann, R., Avar, M., Heinzer, D., Hornemann, S., Wagner, J., Kirschenbaum, D., Voigt, F. F., Zhu, C., Regli, L., Helmchen, F., & Aguzzi, A. (2018). Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier. PLoS Pathogens, 14, e1007424. https://doi.org/10.1371/journal.ppat.1007424
Abstract
Abstract
Abstract
Transmissible spongiform encephalopathies (TSEs) are caused by the prion, which consists essentially of PrPSc, an aggregated, conformationally modified form of the cellular prion protein (PrPC). Although TSEs can be experimentally transmitted by intracerebral inoculation, most instances of infection in the field occur through extracerebral routes. The epidemics of kuru and variant Creutzfeldt-Jakob disease were caused by dietary exposure to prions, and parenteral administration of prion-contaminated hormones has caused hundreds of iat
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Creators (Authors)
- Keller, Annika
- Nuvolone, Mario
- Abakumova, Irina
- Chincisan, Andra
- Reimann, Regina
- Avar, Merve
- Hornemann, Simone
- Wagner, Josephin
- Kirschenbaum, Daniel
- Voigt, Fabian F
- Zhu, Caihong
- Regli, Luca
- Helmchen, Fritjof
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Keller, A., Nuvolone, M., Abakumova, I., Chincisan, A., Reimann, R., Avar, M., Heinzer, D., Hornemann, S., Wagner, J., Kirschenbaum, D., Voigt, F. F., Zhu, C., Regli, L., Helmchen, F., & Aguzzi, A. (2018). Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier. PLoS Pathogens, 14, e1007424. https://doi.org/10.1371/journal.ppat.1007424
