Publication: Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide
Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide
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Garcia, P. L., Liu, Y., Jiricny, J., West, S. C., & Janscak, P. (2004). Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. The EMBO Journal, 23, 2882–2891. https://doi.org/10.1038/sj.emboj.7600301
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Abstract
Proteins belonging to the highly conserved RecQ helicase family are essential for the maintenance of genomic stability. Here, we describe the biochemical properties of the human RECQ5beta protein. Like BLM and WRN, RECQ5beta is an ATP-dependent 3'-5' DNA helicase that can promote migration of Holliday junctions. However, RECQ5beta required the single-stranded DNA-binding protein RPA in order to mediate the efficient unwinding of oligonucleotide-based substrates. Surprisingly, we found that RECQ5beta possesses an intrinsic DNA strand-a
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- Garcia, P L
- Liu, Y
- Jiricny, J
- West, S C
- Janscak, Pavel
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Garcia, P. L., Liu, Y., Jiricny, J., West, S. C., & Janscak, P. (2004). Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. The EMBO Journal, 23, 2882–2891. https://doi.org/10.1038/sj.emboj.7600301
