Publication: Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity
Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity
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Thiel, C. S., Paulsen, K., Bradacs, G., Lust, K., Tauber, S., Dumrese, C., Hilliger, A., Schoppmann, K., Biskup, J., Gölz, N., Sang, C., Ziegler, U., Grote, K.-H., Zipp, F., Zhuang, F., Engelmann, F., Hemmersbach, R., Cogoli, A., & Ullrich, O. (2012). Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity. Cell Communication and Signaling, 10, 1. https://doi.org/10.1186/1478-811X-10-1
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ABSTRACT: In our study we aimed to identify rapidly reacting gravity-responsive mechanisms in mammalian cells in order to understand if and how altered gravity is translated into a cellular response. In a combination of experiments using "functional weightlessness" provided by 2D-clinostats and real microgravity provided by several parabolic flight campaigns and compared to in-flight-1g-controls, we identified rapid gravity-responsive reactions inside the cell cycle regulatory machinery of human T lymphocytes. In response to 2D clinor
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Thiel, C. S., Paulsen, K., Bradacs, G., Lust, K., Tauber, S., Dumrese, C., Hilliger, A., Schoppmann, K., Biskup, J., Gölz, N., Sang, C., Ziegler, U., Grote, K.-H., Zipp, F., Zhuang, F., Engelmann, F., Hemmersbach, R., Cogoli, A., & Ullrich, O. (2012). Rapid alterations of cell cycle control proteins in human T lymphocytes in microgravity. Cell Communication and Signaling, 10, 1. https://doi.org/10.1186/1478-811X-10-1
