Publication: Selective CBP/EP300 Bromodomain Inhibitors: Novel Epigenetic Tools to Counter TNF-α-Driven Inflammation
Date
Date
Date
2025
Journal Article
Published version
Abstract
Abstract
Abstract
Tumor necrosis factor α (TNF-α) is a central driver of inflammation in autoimmune conditions such as Crohn's disease and rheumatoid arthritis (RA). Targeting epigenetic regulators involved in cytokine expression holds therapeutic promise, yet the precise role of the CBP/EP300 bromodomains (BRDs) in modulating immune responses remains poorly understood. Here, we introduce a distinct class of selective CBP/EP300-BRD inhibitors based on a unique 3-methylcinnoline acetyl-lysine mimic, identified through high-throughput fragment docking. T
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14 since deposited on 2025-07-04
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Acq. date: 2025-11-12
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83 since deposited on 2025-07-04
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Additional indexing
Creators (Authors)
- Gosselé, Katherine A
- Latino, Irene
- Laul, Eleen
- Kirillova, Mariia S
- Pascanu, Vlad
- Carloni, Emanuele
- Bedi, Rajiv K
- Pizzichetti, Chiara
- Caflisch, Amedeo
- González, Santiago F
- Nevado, Cristina
Volume
Volume
Volume
5
Number
Number
Number
6
Page range/Item number
Page range/Item number
Page range/Item number
2491
Page end
Page end
Page end
2499
Item Type
Item Type
Item Type
Journal Article
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2025-06-05
Date available
Date available
Date available
2025-07-04
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
2691-3704
OA Status
OA Status
OA Status
Gold
Free Access at
Free Access at
Free Access at
DOI
Publisher DOI
Metrics
Downloads
14 since deposited on 2025-07-04
11last week
Acq. date: 2025-11-12
Views
83 since deposited on 2025-07-04
77last week
Acq. date: 2025-11-12
Citations
Gold Open Access
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