Publication: Protective anti‐prion antibodies in human immunoglobulin repertoires
Protective anti‐prion antibodies in human immunoglobulin repertoires
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Senatore, A., Frontzek, K., Emmenegger, M., Chincisan, A., Losa, M., Reimann, R., Horny, G., Guo, J., Fels, S., Sorce, S., Zhu, C., George, N., Ewert, S., Pietzonka, T., Hornemann, S., & Aguzzi, A. (2020). Protective anti‐prion antibodies in human immunoglobulin repertoires. EMBO Molecular Medicine, e12739. https://doi.org/10.15252/emmm.202012739
Abstract
Abstract
Abstract
Prion immunotherapy may hold great potential, but antibodies against certain PrP epitopes can be neurotoxic. Here, we identified > 6,000 PrP‐binding antibodies in a synthetic human Fab phage display library, 49 of which we characterized in detail. Antibodies directed against the flexible tail of PrP conferred neuroprotection against infectious prions. We then mined published repertoires of circulating B cells from healthy humans and found antibodies similar to the protective phage‐derived antibodies. When expressed recombinantly, thes
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Creators (Authors)
- Senatore, Assunta
- Frontzek, Karl
- Emmenegger, Marc
- Chincisan, Andra
- Losa, Marco
- Horny, Geraldine
- Guo, Jingjing
- Fels, Sylvie
- Sorce, Silvia
- Zhu, Caihong
- George, Nathalie
- Ewert, Stefan
- Pietzonka, Thomas
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Citations
Senatore, A., Frontzek, K., Emmenegger, M., Chincisan, A., Losa, M., Reimann, R., Horny, G., Guo, J., Fels, S., Sorce, S., Zhu, C., George, N., Ewert, S., Pietzonka, T., Hornemann, S., & Aguzzi, A. (2020). Protective anti‐prion antibodies in human immunoglobulin repertoires. EMBO Molecular Medicine, e12739. https://doi.org/10.15252/emmm.202012739
