Publication: Fluorescent dATP for DNA Synthesis In Vivo
Fluorescent dATP for DNA Synthesis In Vivo
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Schreier, V. N., Loehr, M. O., Deng, T., Lattmann, E., Hajnal, A., Neuhauss, S. C. F., & Luedtke, N. W. (2020). Fluorescent dATP for DNA Synthesis In Vivo. ACS Chemical Biology, 15(11), 2996–3003. https://doi.org/10.1021/acschembio.0c00654
Abstract
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Abstract
Fluorescent nucleoside triphosphates are powerful probes of DNA synthesis, but their potential use in living animals has been previously underexplored. Here, we report the synthesis and characterization of 7-deaza-(1,2,3-triazole)-2'-deoxyadenosine-5'-triphosphate (dATP) derivatives of tetramethyl rhodamine ("TAMRA-dATP"), cyanine ("Cy3-dATP"), and boron-dipyrromethene ("BODIPY-dATP"). Upon microinjection into live zebrafish embryos, all three compounds were incorporated into the DNA of dividing cells; however, their impact on embryon
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Creators (Authors)
- Schreier, Verena N
- Loehr, Morten O
- Deng, Ting
- Lattmann, Evelyn
- Luedtke, Nathan W
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Citations
Schreier, V. N., Loehr, M. O., Deng, T., Lattmann, E., Hajnal, A., Neuhauss, S. C. F., & Luedtke, N. W. (2020). Fluorescent dATP for DNA Synthesis In Vivo. ACS Chemical Biology, 15(11), 2996–3003. https://doi.org/10.1021/acschembio.0c00654
