Publication: The biological function of the cellular prion protein: an update
The biological function of the cellular prion protein: an update
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Wulf, M.-A., Senatore, A., & Aguzzi, A. (2017). The biological function of the cellular prion protein: an update. BMC Biology, 15, 34. https://doi.org/10.1186/s12915-017-0375-5
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The misfolding of the cellular prion protein (PrPC) causes fatal neurodegenerative diseases. Yet PrPC is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrPC in mice results in well-defined structural and functional alterations in the peripheral nervous system. Many additional phenotypes were ascribed to the lack of PrPC, but some of these were found to arise from genetic artifacts of the underlying mouse models. Here, we revisit the proposed physiologica
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- Wulf, Marie-Angela
- Senatore, Assunta
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Wulf, M.-A., Senatore, A., & Aguzzi, A. (2017). The biological function of the cellular prion protein: an update. BMC Biology, 15, 34. https://doi.org/10.1186/s12915-017-0375-5
