Publication: The meiotic stage of nondisjunction in trisomy 21: determination by using DNA polymorphisms
The meiotic stage of nondisjunction in trisomy 21: determination by using DNA polymorphisms
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Antonarakis, S. E., Petersen, M. B., McInnis, M. G., Adelsberger, P. A., Schinzel, A. A., Binkert, F., Pangalos, C., Raoul, O., Slaugenhaupt, S. A., Hafez, M., Cohen, M. M., Roulson, D., Hoar, D. I., Rudd, N. L., Warren, A. C., Metaxotou, C., Bartsocas, C., & Chakravarti, A. (1992). The meiotic stage of nondisjunction in trisomy 21: determination by using DNA polymorphisms. American Journal of Human Genetics, 50, 544–550.
Abstract
Abstract
Abstract
We have studied DNA polymorphisms at loci in the pericentromeric region on the long arm of chromosome 21 in 200 families with trisomy 21, in order to determine the meiotic origin of nondisjunction. Maintenance of heterozygosity for parental markers in the individual with trisomy 21 was interpreted as resulting from a meiosis I error, while reduction to homozygosity was attributed to a meiosis II error. Nondisjunction was paternal in 9 cases and was maternal in 188 cases, as reported earlier. Among the 188 maternal cases, nondisjunctio
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Creators (Authors)
- Antonarakis, Stylianos E
- Petersen, Michael B
- McInnis, Melvin G
- Adelsberger, Patricia A
- Schinzel, Albert A
- Binkert, Franz
- Pangalos, Constantine
- Raoul, Odile
- Slaugenhaupt, Susan A
- Hafez, Mohamed
- Cohen, Maimon M
- Roulson, Diane
- Hoar, David I
- Rudd, Noreen L
- Warren, Andrew C
- Metaxotou, Caterina
- Bartsocas, Christos
- Chakravarti, Aravinda
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Citations
Antonarakis, S. E., Petersen, M. B., McInnis, M. G., Adelsberger, P. A., Schinzel, A. A., Binkert, F., Pangalos, C., Raoul, O., Slaugenhaupt, S. A., Hafez, M., Cohen, M. M., Roulson, D., Hoar, D. I., Rudd, N. L., Warren, A. C., Metaxotou, C., Bartsocas, C., & Chakravarti, A. (1992). The meiotic stage of nondisjunction in trisomy 21: determination by using DNA polymorphisms. American Journal of Human Genetics, 50, 544–550.
