Publication: Prolonging somatic cell proliferation through constitutive hox gene expression in C. elegans
Prolonging somatic cell proliferation through constitutive hox gene expression in C. elegans
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Heinze, S. D., Berger, S., Engleitner, S., Daube, M., & Hajnal, A. (2023). Prolonging somatic cell proliferation through constitutive hox gene expression in C. elegans. Nature Communications, 14(1), 6850. https://doi.org/10.1038/s41467-023-42644-1
Abstract
Abstract
Abstract
hox genes encode a conserved family of homeodomain transcription factors that are essential to determine the identity of body segments during embryogenesis and maintain adult somatic stem cells competent to regenerate organs. In contrast to higher organisms, somatic cells in C. elegans irreversibly exit the cell cycle after completing their cell lineage and the adult soma cannot regenerate. Here, we show that hox gene expression levels in C. elegans determine the temporal competence of somatic cells to proliferate. Down-regulation of
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- Heinze, Svenia D
- Berger, Simon
- Engleitner, Stefanie
- Daube, Michael
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Citations
Heinze, S. D., Berger, S., Engleitner, S., Daube, M., & Hajnal, A. (2023). Prolonging somatic cell proliferation through constitutive hox gene expression in C. elegans. Nature Communications, 14(1), 6850. https://doi.org/10.1038/s41467-023-42644-1
