Publication: Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease
Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease
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Carrero, L., Antequera, D., Alcalde, I., Megías, D., Figueiro-Silva, J., Merayo-Lloves, J., Municio, C., & Carro, E. (2023). Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease. Acta Neuropathologica Communications, 11, 55. https://doi.org/10.1186/s40478-023-01529-6
Abstract
Abstract
Abstract
The circadian clock is synchronized to the 24 h day by environmental light which is transmitted from the retina to the suprachiasmatic nucleus (SCN) primarily via the retinohypothalamic tract (RHT). Circadian rhythm abnormalities have been reported in neurodegenerative disorders such as Alzheimer's disease (AD). Whether these AD-related changes are a result of the altered clock gene expression, retina degeneration, including the dysfunction in RHT transmission, loss of retinal ganglion cells and its electrophysiological capabilities,
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Creators (Authors)
- Carrero, Laura
- Antequera, Desireé
- Alcalde, Ignacio
- Megías, Diego
- Merayo-Lloves, Jesús
- Municio, Cristins
- Carro, Eva
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Citations
Carrero, L., Antequera, D., Alcalde, I., Megías, D., Figueiro-Silva, J., Merayo-Lloves, J., Municio, C., & Carro, E. (2023). Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s disease. Acta Neuropathologica Communications, 11, 55. https://doi.org/10.1186/s40478-023-01529-6
