Publication: DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome
DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome
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Joshi, R. S., Garg, P., Zaitlen, N., Lappalainen, T., Watson, C. T., Azam, N., Ho, D., Li, X., Antonarakis, S. E., Brunner, H. G., Buiting, K., Cheung, S. W., Coffee, B., Eggermann, T., Francis, D., Geraedts, J. P., Gimelli, G., Jacobson, S. G., Le Caignec, C., … et al. (2016). DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome. American Journal of Human Genetics, 99, 555–566. https://doi.org/10.1016/j.ajhg.2016.06.032
Abstract
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Genomic imprinting is a mechanism in which gene expression varies depending on parental origin. Imprinting occurs through differential epigenetic marks on the two parental alleles, with most imprinted loci marked by the presence of differentially methylated regions (DMRs). To identify sites of parental epigenetic bias, here we have profiled DNA methylation patterns in a cohort of 57 individuals with uniparental disomy (UPD) for 19 different chromosomes, defining imprinted DMRs as sites where the maternal and paternal methylation level
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Creators (Authors)
- Joshi, Ricky S
- Garg, Paras
- Zaitlen, Noah
- Lappalainen, Tuuli
- Watson, Corey T
- Azam, Nidha
- Ho, Daniel
- Li, Xin
- Antonarakis, Stylianos E
- Brunner, Han G
- Buiting, Karin
- Cheung, Sau Wai
- Coffee, Bradford
- Eggermann, Thomas
- Francis, David
- Geraedts, Joep P
- Gimelli, Giorgio
- Jacobson, Samuel G
- Le Caignec, Cedric
- de Leeuw, Nicole
- Liehr, Thomas
- Mackay, Deborah J
- Montgomery, Stephen B
- Pagnamenta, Alistair T
- Papenhausen, Peter
- Robinson, David O
- Ruivenkamp, Claudia
- Schwartz, Charles
- Steiner, Bernhard
- Stevenson, David A
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Joshi, R. S., Garg, P., Zaitlen, N., Lappalainen, T., Watson, C. T., Azam, N., Ho, D., Li, X., Antonarakis, S. E., Brunner, H. G., Buiting, K., Cheung, S. W., Coffee, B., Eggermann, T., Francis, D., Geraedts, J. P., Gimelli, G., Jacobson, S. G., Le Caignec, C., … et al. (2016). DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome. American Journal of Human Genetics, 99, 555–566. https://doi.org/10.1016/j.ajhg.2016.06.032
