Publication: Cystatin F is a biomarker of prion pathogenesis in mice
Cystatin F is a biomarker of prion pathogenesis in mice
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Nuvolone, M., Schmid, N., Miele, G., Sorce, S., Moos, R., Schori, C., Beerli, R. R., Bauer, M., Saudan, P., Dietmeier, K., Lachmann, I., Linnebank, M., Martin, R., Kallweit, U., Kana, V., Rushing, E. J., Budka, H., & Aguzzi, A. (2017). Cystatin F is a biomarker of prion pathogenesis in mice. PLoS ONE, 12, e0171923. https://doi.org/10.1371/journal.pone.0171923
Abstract
Abstract
Abstract
Misfolding of the cellular prion protein (PrPC) into the scrapie prion protein (PrPSc) results in progressive, fatal, transmissible neurodegenerative conditions termed prion diseases. Experimental and epidemiological evidence point toward a protracted, clinically silent phase in prion diseases, yet there is no diagnostic test capable of identifying asymptomatic individuals incubating prions. In an effort to identify early biomarkers of prion diseases, we have compared global transcriptional profiles in brains from pre-symptomatic prio
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Creators (Authors)
- Nuvolone, Mario
- Schmid, Nicolas
- Miele, Gino
- Sorce, Silvia
- Moos, Rita
- Schori, Christian
- Beerli, Roger R
- Bauer, Monika
- Saudan, Philippe
- Dietmeier, Klaus
- Lachmann, Ingolf
- Linnebank, Michael
- Kallweit, Ulf
- Kana, Veronika
- Rushing, Elisabeth J
- Budka, Herbert
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Nuvolone, M., Schmid, N., Miele, G., Sorce, S., Moos, R., Schori, C., Beerli, R. R., Bauer, M., Saudan, P., Dietmeier, K., Lachmann, I., Linnebank, M., Martin, R., Kallweit, U., Kana, V., Rushing, E. J., Budka, H., & Aguzzi, A. (2017). Cystatin F is a biomarker of prion pathogenesis in mice. PLoS ONE, 12, e0171923. https://doi.org/10.1371/journal.pone.0171923
