Publication: Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency
Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency
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Labouesse, M. A., Lassalle, O., Richetto, J., Iafrati, J., Weber-Stadlbauer, U., Notter, T., Gschwind, T., Pujadas, L., Soriano, E., Reichelt, A. C., Labouesse, C., Langhans, W., Chavis, P., & Meyer, U. (2017). Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency. Molecular Psychiatry, 22(7), 961–971. https://doi.org/10.1038/mp.2016.193
Abstract
Abstract
Abstract
Overconsumption of high-fat diets (HFDs) can critically affect synaptic and cognitive functions within telencephalic structures such as the medial prefrontal cortex (mPFC). The underlying mechanisms, however, remain largely unknown. Here we show that adolescence is a sensitive period for the emergence of prefrontal cognitive deficits in response to HFD. We establish that the synaptic modulator reelin (RELN) is a critical mediator of this vulnerability because (1) periadolescent HFD (pHFD) selectively downregulates prefrontal RELN(+) c
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Creators (Authors)
- Labouesse, M A
- Lassalle, O
- Richetto, J
- Iafrati, J
- Weber-Stadlbauer, U
- Notter, T
- Gschwind, T
- Pujadas, L
- Soriano, E
- Reichelt, A C
- Labouesse, C
- Langhans, W
- Chavis, P
- Meyer, U
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Citations
Labouesse, M. A., Lassalle, O., Richetto, J., Iafrati, J., Weber-Stadlbauer, U., Notter, T., Gschwind, T., Pujadas, L., Soriano, E., Reichelt, A. C., Labouesse, C., Langhans, W., Chavis, P., & Meyer, U. (2017). Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency. Molecular Psychiatry, 22(7), 961–971. https://doi.org/10.1038/mp.2016.193
