Publication: Immunity-Based Evolutionary Interpretation of Diet-Induced Thermogenesis
Immunity-Based Evolutionary Interpretation of Diet-Induced Thermogenesis
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Liao, W.-H., Henneberg, M., & Langhans, W. (2016). Immunity-Based Evolutionary Interpretation of Diet-Induced Thermogenesis. Cell Metabolism, 23(6), 971–979. https://doi.org/10.1016/j.cmet.2016.05.002
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Diet-induced thermogenesis (DIT) has often been argued to be a physiological defense against obesity, but no empirical proof of its effectiveness in limiting human body weight gain is available. We here propose an immune explanation of DIT-i.e., that it results from the coevolution of host and gut microbiota (especially Firmicutes) that ferment ingested food and proliferate, causing periodic, vagally mediated increases in thermogenesis aimed at curtailing their expansion. Because of this evolutionary adaptive significance related to t
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- Liao, Wan-Hui
- Henneberg, Maciej
- Langhans, Wolfgang
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Liao, W.-H., Henneberg, M., & Langhans, W. (2016). Immunity-Based Evolutionary Interpretation of Diet-Induced Thermogenesis. Cell Metabolism, 23(6), 971–979. https://doi.org/10.1016/j.cmet.2016.05.002