Publication: The Calcium-Sensing Receptor in the Thick Ascending Limb and the Renal Response to Hypercalcemia
The Calcium-Sensing Receptor in the Thick Ascending Limb and the Renal Response to Hypercalcemia
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Himmerkus, N., Quintanova, C., Bhullar, H., van Megen, W. H., Deluque, A. L., Skjødt, K., Bogdanovic, M., Bleich, M., Alexander, T., & Dimke, H. (2025). The Calcium-Sensing Receptor in the Thick Ascending Limb and the Renal Response to Hypercalcemia. Journal of the American Society of Nephrology (JASN), 36(6), 1028–1039. https://doi.org/10.1681/ASN.0000000612
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BACKGROUND: The parathyroid calcium-sensing receptor (CASR) controls the release of parathyroid hormone (PTH) in response to changes in serum calcium levels. Activation of the renal CASR increases urinary calcium excretion and is particularly important when CASR-dependent reductions in PTH fail to lower serum calcium. However, the role of the renal CASR in protecting against hypercalcemia and the direct effects of chronic CASR activation on tubular calcium handling remains to be fully elucidated.
METHODS: Experimental hypercalcemia w
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Himmerkus, N., Quintanova, C., Bhullar, H., van Megen, W. H., Deluque, A. L., Skjødt, K., Bogdanovic, M., Bleich, M., Alexander, T., & Dimke, H. (2025). The Calcium-Sensing Receptor in the Thick Ascending Limb and the Renal Response to Hypercalcemia. Journal of the American Society of Nephrology (JASN), 36(6), 1028–1039. https://doi.org/10.1681/ASN.0000000612
