Publication: Ciliary control of meiotic chromosomal pairing mechanics and germ cell morphogenesis
Ciliary control of meiotic chromosomal pairing mechanics and germ cell morphogenesis
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Mytils, A., Kumar, V., Tao, Q., Deis, R., Levy, K., Masek, M., Eitan, H., Nather, F., Shawahny, A., Bachmann-Gagescu, R., Roy, S., & Elkouby, Y. M. (2021). Ciliary control of meiotic chromosomal pairing mechanics and germ cell morphogenesis (No. 430249; BioRxiv). https://doi.org/10.1101/2021.02.08.430249
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Meiosis is a cellular program essential for the production of haploid gametes. A hallmark of meiosis is chromosomal pairing via synaptonemal complexes, and a major focus traditionally has been to understand synaptonemal complex formation. However, chromosomal pairing also depends on cytoplasmic counterparts that tether and rotate telomeres on the nuclear envelope, shuffling chromosomes and mechanically driving their homology searches1–8. Rotating telomeres slide on perinuclear microtubules and are ultimately pulled towards the centros
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Mytils, A., Kumar, V., Tao, Q., Deis, R., Levy, K., Masek, M., Eitan, H., Nather, F., Shawahny, A., Bachmann-Gagescu, R., Roy, S., & Elkouby, Y. M. (2021). Ciliary control of meiotic chromosomal pairing mechanics and germ cell morphogenesis (No. 430249; BioRxiv). https://doi.org/10.1101/2021.02.08.430249
