Publication: Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy
Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy
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Sorrentino, S. A., Besler, C., Rohrer, L., Meyer, M., Heinrich, K., Bahlmann, F. H., Mueller, M., Horváth, T., Doerries, C., Heinemann, M., Flemmer, S., Markowski, A., Manes, C., Bahr, M. J., Haller, H., von Eckardstein, A., Drexler, H., & Landmesser, U. (2010). Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy. Circulation, 121(1), 110–122. https://doi.org/10.1161/CIRCULATIONAHA.108.836346
Abstract
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Abstract
BACKGROUND: High-density lipoprotein (HDL)-raising therapies are currently under intense evaluation, but the effects of HDL may be highly heterogeneous. We therefore compared the endothelial effects of HDL from healthy subjects and from patients with type 2 diabetes mellitus and low HDL (meeting the criteria for metabolic syndrome), who are frequently considered for HDL-raising therapies. Moreover, in diabetic patients, we examined the impact of extended-release (ER) niacin therapy on the endothelial effects of HDL. METHODS AND RESULT
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Creators (Authors)
- Sorrentino, S A
- Besler, C
- Rohrer, L
- Meyer, Martin
- Heinrich, K
- Bahlmann, F H
- Mueller, M
- Horváth, T
- Doerries, C
- Heinemann, M
- Flemmer, S
- Markowski, A
- Manes, C
- Bahr, M J
- Haller, H
- von Eckardstein, Arnold
- Drexler, H
- Landmesser, U
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Citations
Sorrentino, S. A., Besler, C., Rohrer, L., Meyer, M., Heinrich, K., Bahlmann, F. H., Mueller, M., Horváth, T., Doerries, C., Heinemann, M., Flemmer, S., Markowski, A., Manes, C., Bahr, M. J., Haller, H., von Eckardstein, A., Drexler, H., & Landmesser, U. (2010). Endothelial-vasoprotective effects of high-density lipoprotein are impaired in patients with type 2 diabetes mellitus but are improved after extended-release niacin therapy. Circulation, 121(1), 110–122. https://doi.org/10.1161/CIRCULATIONAHA.108.836346
