Publication: Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy
Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy
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Wu Klingler, W., Giger, N., Schneider, L., Babu, V., König, C., Spielmann, P., Wenger, R. H., Ferrari, S., & Spingler, B. (2022). Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy. International Journal of Molecular Sciences, 23(17), 9525. https://doi.org/10.3390/ijms23179525
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Phthalocyanines (Pcs) are promising candidates for photodynamic therapy (PDT) due to their absorption in the phototherapeutic window. However, the highly aromatic Pc core leads to undesired aggregation and decreased reactive oxygen species (ROS) production. Therefore, short PEG chain functionalized A3B type asymmetric Pc photosensitizers (PSs) were designed in order to decrease aggregation and increase the aqueous solubility. Here we report the synthesis, characterization, optical properties, cellular localization, and cytotoxicity of
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Wu Klingler, W., Giger, N., Schneider, L., Babu, V., König, C., Spielmann, P., Wenger, R. H., Ferrari, S., & Spingler, B. (2022). Low-Dose Near-Infrared Light-Activated Mitochondria-Targeting Photosensitizers for PDT Cancer Therapy. International Journal of Molecular Sciences, 23(17), 9525. https://doi.org/10.3390/ijms23179525
