Publication: Differential toxicity of antibodies to the prion protein
Differential toxicity of antibodies to the prion protein
Date
Date
Date
Citations
Reimann, R. R., Sonati, T., Hornemann, S., Herrmann, U. S., Arand, M., Hawke, S., & Aguzzi, A. (2016). Differential toxicity of antibodies to the prion protein. PLoS Pathogens, 12(1), e1005401. https://doi.org/10.1371/journal.ppat.1005401
Abstract
Abstract
Abstract
Antibodies against the prion protein PrPC can antagonize prion replication and neuroinvasion, and therefore hold promise as possible therapeutics against prion diseases. However, the safety profile of such antibodies is controversial. It was originally reported that the monoclonal antibody D13 exhibits strong target-related toxicity, yet a subsequent study contradicted these findings. We have reported that several antibodies against certain epitopes of PrPC, including antibody POM1, are profoundly neurotoxic, yet antibody ICSM18, with
Metrics
Downloads
Views
Additional indexing
Creators (Authors)
- Reimann, Regina R
- Sonati, Tiziana
- Hornemann, Simone
- Herrmann, Uli S
- Arand, Michael
- Hawke, Simon
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Reimann, R. R., Sonati, T., Hornemann, S., Herrmann, U. S., Arand, M., Hawke, S., & Aguzzi, A. (2016). Differential toxicity of antibodies to the prion protein. PLoS Pathogens, 12(1), e1005401. https://doi.org/10.1371/journal.ppat.1005401
