Publication: RNA oligomers at atomic resolution containing 1‐methylpseudouridine, an essential building block of mRNA vaccines
RNA oligomers at atomic resolution containing 1‐methylpseudouridine, an essential building block of mRNA vaccines
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Nievergelt, P., Berliat, F., McAuley, K. E., Dorgan, C. R., van Well, R. M., Thorn, A., & Spingler, B. (2024). RNA oligomers at atomic resolution containing 1‐methylpseudouridine, an essential building block of mRNA vaccines. ChemMedChem, 19(7), e202300600. https://doi.org/10.1002/cmdc.202300600
Abstract
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Abstract
All widely used mRNA vaccines against COVID‐19 contain in their sequence 1‐methylpseudouridine (m1Ψ) instead of uridine. In this publication, we report two high resolution crystal structures (at up to 1.01 and 1.32 Å, respectively) of one such double‐stranded 12‐mer RNA sequence crystallized in two crystal forms. The structures are compared with similar structures which do not contain this modification. Additionally, the X‐ray structure of 1‐methyl‐pseudouridine itself was determined.
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- Nievergelt, Philipp
- Berliat, Florian
- McAuley, Katherine E
- Dorgan, Colin R
- van Well, Renate Maria
- Thorn, Andrea
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Nievergelt, P., Berliat, F., McAuley, K. E., Dorgan, C. R., van Well, R. M., Thorn, A., & Spingler, B. (2024). RNA oligomers at atomic resolution containing 1‐methylpseudouridine, an essential building block of mRNA vaccines. ChemMedChem, 19(7), e202300600. https://doi.org/10.1002/cmdc.202300600
