Identification of inflammatory subgroups of schizophrenia and bipolar disorder patients with HERV-W ENV antigenemia by unsupervised cluster analysis

Tamouza, Ryad; Meyer, Urs; Foiselle, Marianne; Richard, Jean-Romain; Wu, Ching-Lien; Boukouaci, Wahid; Le Corvoisier, Philippe; Barrau, Caroline; Lucas, Alexandre; Perron, Hervé; Leboyer, Marion

doi:10.1038/s41398-021-01499-0

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Tamouza, R., Meyer, U., Foiselle, M., Richard, J.-R., Wu, C.-L., Boukouaci, W., Le Corvoisier, P., Barrau, C., Lucas, A., Perron, H., & Leboyer, M. (2021). Identification of inflammatory subgroups of schizophrenia and bipolar disorder patients with HERV-W ENV antigenemia by unsupervised cluster analysis. Translational Psychiatry, 11(1), 377. https://doi.org/10.1038/s41398-021-01499-0

Abstract

Human endogenous retroviruses (HERVs) are remnants of infections that took place several million years ago and represent around 8% of the human genome. Despite evidence implicating increased expression of HERV type W envelope (HERV-W ENV) in schizophrenia and bipolar disorder, it remains unknown whether such expression is associated with distinct clinical or biological characteristics and symptoms. Accordingly, we performed unsupervised two-step clustering of a multivariate data set that included HERV-W ENV protein antigenemia, serum