Abscisic acid is a substrate of the ABC transporter encoded by the durable wheat disease resistance gene Lr34

Krattinger, Simon G; Kang, Joohyun; Bräunlich, Stephanie; Boni, Rainer; Chauhan, Harsh; Selter, Liselotte L; Robinson, Mark D; Schmid, Marc W; Wiederhold, Elena; Hensel, Goetz; Kumlehn, Jochen; Sucher, Justine; Martinoia, Enrico; Keller, Beat

doi:10.1111/nph.15815

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Krattinger, S. G., Kang, J., Bräunlich, S., Boni, R., Chauhan, H., Selter, L. L., Robinson, M. D., Schmid, M. W., Wiederhold, E., Hensel, G., Kumlehn, J., Sucher, J., Martinoia, E., & Keller, B. (2019). Abscisic acid is a substrate of the ABC transporter encoded by the durable wheat disease resistance gene Lr34. New Phytologist, 223(2), 853–866. https://doi.org/10.1111/nph.15815

Abstract

The wheat Lr34res allele, coding for an ATP-binding cassette transporter, confers durable resistance against multiple fungal pathogens. The Lr34sus allele, differing from Lr34res by two critical nucleotide polymorphisms, is found in susceptible wheat cultivars. Lr34res is functionally transferrable as a transgene into all major cereals, including rice, barley, maize, and sorghum. Here, we used transcriptomics, physiology, genetics, and in vitro and in vivo transport assays to study the molecular function of Lr34. We report that Lr34re