Publication: Synthesis of Cyclohexapeptides containing Pro and Aib residues
Synthesis of Cyclohexapeptides containing Pro and Aib residues
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Jeremic, T., Linden, A., & Heimgartner, H. (2004). Synthesis of Cyclohexapeptides containing Pro and Aib residues. Helvetica Chimica Acta, 87, 3056–3079. https://doi.org/10.1002/hlca.200490275
Abstract
Abstract
Abstract
Cyclization reactions on hexapeptides containing several alpha-aminoisobutyric acid (= 2-amino-2-methylpropanoic acid; Aib) residues and the turn-promoting glycine (Gly) and proline (Pro) residues were investigated. Eight linear hexapeptides were synthesized, and their cyclization was attempted with various coupling reagents. The macrolactamization step proved to be difficult since only three hexapeptides could be cyclized. Two of these latter peptides were the linear precursors of the same cyclic hexapeptide, cyclo(Aib-Aib-Phe-Pro-Ai
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- Jeremic, Tatjana
- Heimgartner, Heinz
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Citations
Jeremic, T., Linden, A., & Heimgartner, H. (2004). Synthesis of Cyclohexapeptides containing Pro and Aib residues. Helvetica Chimica Acta, 87, 3056–3079. https://doi.org/10.1002/hlca.200490275
