Publication: XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death
XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death
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Oishi, N., Duscha, S., Boukari, H., Meyer, M., Xie, J., Wei, G., Schrepfer, T., Roschitzki, B., Böttger, E. C., & Schacht, J. (2015). XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. Cell Death and Disease, 6(e1763), online. https://doi.org/10.1038/cddis.2015.108
Abstract
Abstract
Abstract
Here we study links between aminoglycoside-induced mistranslation, protein misfolding and neuropathy. We demonstrate that aminoglycosides induce misreading in mammalian cells and assess endoplasmic reticulum (ER) stress and unfolded protein response (UPR) pathways. Genome-wide transcriptome and proteome analyses revealed upregulation of genes related to protein folding and degradation. Quantitative PCR confirmed induction of UPR markers including C/EBP homologous protein, glucose-regulated protein 94, binding immunoglobulin protein an
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Creators (Authors)
- Oishi, Naoki
- Duscha, Stefan
- Boukari, Heithem
- Meyer, Martin
- Xie, Jing
- Wei, Gao
- Schrepfer, Thomas
- Roschitzki, Bernd
- Böttger, Erik C
- Schacht, Jochen
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Citations
Oishi, N., Duscha, S., Boukari, H., Meyer, M., Xie, J., Wei, G., Schrepfer, T., Roschitzki, B., Böttger, E. C., & Schacht, J. (2015). XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. Cell Death and Disease, 6(e1763), online. https://doi.org/10.1038/cddis.2015.108
