Publication: DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma
DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma
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Strubel, A., Münick, P., Hartmann, O., Chaikuad, A., Dreier, B., Schaefer, J. V., Gebel, J., Osterburg, C., Tuppi, M., Schäfer, B., Buck, V., Rosenfeldt, M., Knapp, S., Plückthun, A., Diefenbacher, M. E., & Dötsch, V. (2023). DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma. Cell Death and Disease, 14(10), 674. https://doi.org/10.1038/s41419-023-06213-0
Abstract
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Abstract
The two p53 homologues p63 and p73 regulate transcriptional programs in epithelial tissues and several cell types in these tissues express both proteins. All members of the p53 family form tetramers in their active state through a dedicated oligomerization domain that structurally assembles as a dimer of dimers. The oligomerization domain of p63 and p73 share a high sequence identity, but the p53 oligomerization domain is more divergent and it lacks a functionally important C-terminal helix present in the other two family members. Bas
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- Strubel, Alexander
- Münick, Philipp
- Hartmann, Oliver
- Chaikuad, Apirat
- Dreier, Birgit
- Schaefer, Jonas V
- Gebel, Jakob
- Osterburg, Christian
- Tuppi, Marcel
- Schäfer, Birgit
- Buck, Viktoria
- Rosenfeldt, Mathias
- Knapp, Stefan
- Diefenbacher, Markus E
- Dötsch, Volker
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Strubel, A., Münick, P., Hartmann, O., Chaikuad, A., Dreier, B., Schaefer, J. V., Gebel, J., Osterburg, C., Tuppi, M., Schäfer, B., Buck, V., Rosenfeldt, M., Knapp, S., Plückthun, A., Diefenbacher, M. E., & Dötsch, V. (2023). DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma. Cell Death and Disease, 14(10), 674. https://doi.org/10.1038/s41419-023-06213-0
