Publication: Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake
Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake
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Urry, E., Jetter, A., & Landolt, H.-P. (2016). Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake. Nutrition & Metabolism, 13, 66. https://doi.org/10.1186/s12986-016-0126-6
Abstract
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Abstract
BACKGROUND Coffee consumption is a known inducer of cytochrome P450 1A2 (CYP1A2) enzyme activity. We recently observed that a group of type-2 diabetes patients consumed more caffeine (coffee) on a daily basis than non-type-2 diabetes controls. Here, we investigated whether type-2 diabetes cases may metabolize caffeine faster than non-type-2 diabetes controls. METHODS To estimate CYP1A2 enzyme activity, an established marker of caffeine metabolism, we quantified the paraxanthine/caffeine concentration ratio in saliva in 57 type-2 diabe
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- Urry, Emily
- Jetter, Alexander
- Landolt, Hans-Peter
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Urry, E., Jetter, A., & Landolt, H.-P. (2016). Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake. Nutrition & Metabolism, 13, 66. https://doi.org/10.1186/s12986-016-0126-6
