Picolylamine-methylphosphonic acid esters as tridentate ligands for the labeling of alcohols with the fac-[M(CO)3]+ core (M = 99mTc, Re): synthesis and biodistribution of model compounds and of a 99mTc-labeled cobinamide.

Mundwiler, S; Waibel, R; Spingler, B; Kunze, S; Alberto, R

doi:10.1016/j.nucmedbio.2005.04.007

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Mundwiler, S., Waibel, R., Spingler, B., Kunze, S., & Alberto, R. (2005). Picolylamine-methylphosphonic acid esters as tridentate ligands for the labeling of alcohols with the fac-[M(CO)3]+ core (M = 99mTc, Re): synthesis and biodistribution of model compounds and of a 99mTc-labeled cobinamide. Nuclear Medicine and Biology, 32(5), 473–484. https://doi.org/10.1016/j.nucmedbio.2005.04.007

Abstract

[(Methyl-pyridin-2-ylmethyl-amino)-methyl]-phosphonic acid is a new bifunctional chelator for the fac-(99m)Tc(CO(3)) core which can be linked to biomolecules via formation of phosphonic acid esters. Its synthesis and the coupling to model alcohols and to a bioactive molecule (cobinamide) are described. The rhenium complexes [Re(CO)(3)L] of the esters have been prepared and characterized, one of them by X-ray crystallography. The model esters could be labeled with (99m)Tc(OH(2))(3)(CO)(3) under mild conditions and relatively